Exploring protein domain structure
نویسندگان
چکیده
منابع مشابه
Exploring protein domain structure.
The protein databank contains coordinates of over 10,000 protein structures, which constitute more than 25,000 structural domains in total. The investigation of protein structural, functional and evolutionary relationships is fundamental to many important fields in bioinformatics research, and will be crucial in determining the function of the human and other genomes. This review describes the ...
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Domain hierarchy and closed loops (DHcL) (http://sitron.bccs.uib.no/dhcl/) is a web server that delineates energy hierarchy of protein domain structure and detects domains at different levels of this hierarchy. The server also identifies closed loops and van der Waals locks, which constitute a structural basis for the protein domain hierarchy. The DHcL can be a useful tool for an express analys...
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MOTIVATION Protein domains are fundamental units of protein structure, function and evolution; thus, it is critical to gain a deep understanding of protein domain organization. Previous works have attempted to identify key residues involved in organization of domain architecture. Because one of the most important characteristics of domain architecture is the arrangement of secondary structure e...
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Proteins are the most abundant and diverse class of biomolecules that mediate the vast majority of biochemical processes. The functional units within a protein are the ”domains” which fold autonomously from the rest of the linear amino acid sequence in the protein. Novelty in protein function often arises as a result of gain, loss or re-shuffling of existing domains. Thus, protein domains can a...
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UNLABELLED Conserved domains represent essential building blocks of most known proteins. Owing to their role as modular components carrying out specific functions they form a network based both on functional relations and direct physical interactions. We have previously shown that domain interaction networks provide substantially novel information with respect to networks built on full-length p...
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ژورنال
عنوان ژورنال: Briefings in Bioinformatics
سال: 2000
ISSN: 1467-5463,1477-4054
DOI: 10.1093/bib/1.3.305